Sitting down with: Bent Jakobsen, Immunocore

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Dr. Bent Jakobsen gained first-hand insight into the foundational discoveries of the life sciences during his PhD studies at the Laboratory of Molecular Biology in Cambridge. At the LMB, not only was DNA structure, the genetic code and the invention of protein crystallography discovered, but also monoclonal antibodies (mAbs). The work pioneered by Cesar Milstein and Greg Winter on mAbs, amongst others, was Bent’s inspiration for the idea that led to Immunocore, of which he is the scientific founder.

What does Immunocore do?

Immunocore uses human T cell receptors (TCRs) to generate novel types of drugs. TCRs are present on T cells, which are immune cells whose role is to destroy infected cells. TCRs have many similarities – and many differences – to antibodies. Like antibodies, TCRs are generated in humans in a repertoire of huge diversity and can be generated against cancer, infectious diseases and autoimmune diseases. But unlike antibodies, TCRs can target intracellular proteins, which provides us with…

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