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David Kyle, Evolve Biosystems

March 27, 2019 Jane 0

Dr. David Kyle has co-founded biotech companies for 35 years in nutrition and health including Martek Biosciences which was acquired in 2011 for $1.1 billion. For the first issue of Biostart, he spoke to us about the lessons he’s learned during his career.

Where did Evolve begin?

Evolve’s work is based on 15 years of previous research at the University of California at Davis. A cross-functional team of world-class scientists made an incredible discovery. The early microbiome of the infant is defined by the 15% of energy in human breast milk that is not directly available to the infant, but rather it is tied up in a soluble fibre (Human Milk Oligosaccharides or HMO) that feeds the new-born infant gut microbiome.

Interestingly, only a single bacterial species, Bifidobacterial infantis, has the capability for completely consuming all those HMO and remarkably, this species has been lost from most infants in the developed world due primarily to a lifetime exposure to antibiotics. The seeding of an infant’s gut microbiome has historically come from its mother’s gut microbiome, but mothers in the U.S. today have had 15-20 courses of antibiotics from the time they were born until the time they deliver their first baby. Her microbiome diversity has been depleted significantly, including this important symbiont and if mom does not have the B. infantis, she cannot pass it on to her baby and the symbiosis has…

Attached Issue № 0219

Investing in the future

March 13, 2019 Jane 0

Charlie Curtis teaches businesses how to innovate, focusing on the positive impact they can have for future generations. But keen to have a positive impact himself, Charlie, alongside his business partner Tim Kruger, starts revolutionary new ventures to address environmental issues.

Everyone should have a wilderness experience where they walk across a desert or climb a mountain or cycle across a country. In 2008, I spent three months in a small boat with three others, sailing from Argentina to Cape Town via the Antarctic. The camaraderie with a team that size is…

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Editor’s Note: The Microbiome Special

March 6, 2019 Jane 0

Oxford is an inspiring place to live. Aside from the dreaming spires, famous alumni and culture of learning, it is home to an impressive number of biotech start-ups. Coupled with Cambridge and London, the number of start-ups in the area is booming.

I moved to Oxford, not for university like most do, but instead to work with scientists, helping them disseminate their knowledge, first through academic publishing and later in the conference industry. It’s been my pleasure to meet with scientists from all over the world, not just from the UK, but from across Europe, North America and Asia to find out not only what excites them about the future of the industry, but to discuss…

Attached Issue № 0219